BREAKING AND MAKING BONDS UNDER A CAVITY STRESS WITH BIOMIMETIC METAL COMPLEXES – STRESSMETCHEM

In the literature, many publications highlighting the development of new synthetic methods consist in forming or, more rarely, breaking chemical bonds. In both cases, organic chemists are facing reactivity and chemo or regio-selectivity problems. Nature has developed powerful tools for chemistry, notably metallo-enzymes. They are able to catalyze a large number of reactions of bond formation or cleavage with an outstanding efficiency. This efficiency is obviously not only due to the common motif co-facial triad/metal ion but also to the remarkable pre-organization of the catalyst vs reactants that must be crucial to direct the chemistry. In this project, we propose a chemical challenge: making and breaking bonds under the supramolecular stress of a cavity (resorcinarene) associated to a biomimetic metal center (Zn, Fe, Ni) and studying the obtained selectivities under cavity control.