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Responsive Probes for the quantitative detection of Zn(II) and Cu(II) by MRI and PET/SPECT – ZiCoRes
The assessment and understanding of metal distribution in living systems by non-invasive imaging is crucial to give more insight into metal homeostasis as well as into diseases involving metal misregulation and could ultimately contribute to their proper treatment. The aim of this project after four
Developing new inhibitors against flavivirus methyltransferase using a 'Fragment-Based Drug Discovery' strategy – FragVir
The main issues and goals of this project are firstly understanding the mechanisms of specific inhibition of viral methyltransferase, and secondly, to provide the basis of a new antiviral strategy targeting RNA maturation of emerging viruses. In the current context, the discovery of antiviral drugs
Deciphering the sorting mechanism of GAGs by chemical synthesis of effectors of glycosaminyltransferases – GAG-Sorting
Despite the fact that most of the GTs involved in the biosynthesis of GAGs have been identified, their molecular mechanism of action remains obscure. We will focuse our study on two human glycosaminyltransferases involved in the biosynthesis : EXTL3 and CSGalNAcT-1. To this end, we propose to devise
Cinnamic-based Turn-ON Fluorescent tools via 2-photon excitation – CiTrON-Fluo
Through this proposal, we precisely intend to provide new, alternative and complementary sets of fluorogenic tools that are non- (or weakly) fluorescent in their native forms (OFF state) and whose turn-ON fluorescence is triggered by light excitation. Of particular note is that our attention will be
Studies in Organocatalysis – STUDORCA
For the one part (Task 1), we propose to develop an diastereo- and enantio-selective flexible organocatalytic approach for the synthesis of spirobicyclic compounds having an “all carbon” spiro carbon atom, using the reactivity of ketoenolate/chiral Lewis base zwiterrionic adducts. For the other par
Helicenes: From and Towards Asymmetric Organometallic Catalysis – HELCATS
Helicenes, aromatic compounds with a helical structure, intrinsically possess interesting chiroptic properties and find applications in various fields. Of particular interest is the preparation of optically enriched helicenes, as the latter are paving the way towards asymmetric catalysis. To date, o
Conception of multi-responsive molecular films incorporating photochromic units and metal complexes – multicom
Stimuli-responsive molecular architectures have long been recognized as the most straightforward and viable choice to produce practical materials and devices. However, a major challenge facing chemists deals with the integration of molecules into devices giving access to the transmission of the mole
alpha-Trifluoromethylated Nitrogen Derivatives: Asymmetric Synthesis and Elaboration of Complex Molecules. – TFM4Asym
Trifluoromethylated compounds have found a wide range of applications as pharmaceuticals, agrochemicals or materials due to the specific properties introduced by the fluorine atoms. Nitrogen containing derivatives in particular are of great interest. Amines are present in a large majority of drugs
Enantioselective halocarbocyclization reactions induced by chiral Lewis bases – ChiNuHalo
The subject of the present proposal deals with the synthesis of new chiral families of Lewis bases and the evaluation of their ability to activate electrophilic halogen sources in order to promote halocarbocyclization reactions. Halogen-containing natural products of potent biological interest indee
Aromatic Nanobelts – ANABEL
When this project was beginning, the controlled organic synthesis of cylindrical shape aromatic molecules was a long time scientific challenge date on which several international research groups were focusing. Several of them obtained very close results but real carbon nanobelts could never be reach
Synthesis of pyrazoline derivatives via [3+2] cyclization. Towards an asymmetric and catalytic version of the reaction. – HUISPHOS
Instead of using a large quantity of phosphine, we suggest to regenerate in situ the catalyst, and so to aim towards a more environmentally friendly chemistry. We developed the first examples of catalytic cyclization reactions between the Huisgen zwitterion and alpha-ketoester derivatives. We verifi
Phosphasalen oxidized complexes – PsalenOx
The originality of this project mainly lies in the nature of the ligand. Whereas, salen ligands were thoroughly investigated for decades both in coordination chemistry and catalysis, and despite the variety of structural variations proposed, only few reports deal with heteroatom substitution on the
Carbene-mediated quaternarization of the anomeric position of N-Acetylglucosamine derivatives – QuatGlcNAc
New synthetic tools in carbohydrate chemistry have attracted tremendous interest over the past decades because of the important role played by complex oligosaccharides in many fundamental biological processes. The aim of this project is to develop the functionalization of the anomeric C-H bond of 2-