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Chromosome dynamics and recombination during meiosis – MeioRec
- The «MeioRec« project aims to elucidate the genetic and physical control of meiotic recombination through complementary approaches. Using S. cerevisiae yeast as a model organism, and taking advantage of the power of its genetics, we are studying the regulation of different recombination pathways b
Genetic variation, transcriptomics and epigenetics in calcific aortic valve stenosis – CavsGen
High-throughput genotyping technologies allow the screening of large cohorts of patients for hundreds of thousands of markers. ‘Genome-wide association studies’, which have been focusing mostly on common variants, have been successful in identifying new biological pathways and new potential therapeu
Integrative analysis of gene families involved in aromatic terpene biosynthesis in grapevine – InteGrape
Aroma compounds synthesized and accumulated in grape berries have a decisive influence on wine quality. The grapevine genome contains large families of terpene synthase genes (TPS) and cytochrome P450 genes (P450), involved in the biosynthesis of terpenes involved in wine aromas. The purpose of this
Mining genomic islands for novel secondary metabolites gene clusters – MiGenIs
Natural products, known as secondary or specialized metabolites (SMs), are low-molecular-weight chemicals produced by living organisms and possessing biological or pharmacological activities. They are a major source of therapeutic molecules, constitute biological probes to study cellular functions a
Identification of Matrix Proteins Affecting Crystal Texture in chicken and guinea fowl eggshells – IMPACT
The chicken egg is a basic ingredient of high quality and relatively low price for human consumption. The egg must remain safe and free of pathogens. Eggs and egg products are used as raw ingredient in food products (e.g. mayonnaise..) and is still a major source of salmonella human infections. The
Energy Conversion Organelles N-terminus proteome: A better understanding of organelle protein maturation – eNergiome
Despite mitochondrial disorders are well known and that the use of chloroplasts for the production of recombinant proteins for therapeutic use has a major advantage, the fate of proteins involved in these organelles is mainly unknown . It is therefore better to understand the fate of these proteins
Retinoic acid receptor-mediated gene repression, from molecular basis to physiological significance – ARREPRESS
The retinoic acid receptors mediate both organismal and cellular effects of retinoid and regulate a wide variety of essential biological processes, as well as their disorders. Retinoic acid receptors are ligand-modulated transcription factors belonging to the nuclear hormone receptor superfamily tha
Uncovering the role of novel histone modifications in transcription and their mechanistic impact on chromatin function – CoreAc
Histone proteins pack the DNA within the nucleus of a cell/ Overall the aim of project is (i) to functionally characterise novel histone modifications, to (ii) significantly advance our understanding of how histone acetylations can regulate transcription, (iii) to try to demonstrate that histone mod
Yeast complex trait genetics: beyond classical crosses – AcrossTrait
1 - RTG of the laboratory S. cerevisiae hybrid S288c/SK1 The initial step of our proposal was to characterize the genome dynamic during the RTG process. This was obtained in a cross between lab strain, genome sequencing and analysis of RTG cells 2 - Genome dynamic in non laboratory strains A ce
Membrane-bound RNase E: role in RNA processing, RNA surveillance and mRNA degradation – memRNase
RNase E, an essential endo-ribonuclease, is part of a large multienzyme complex known as the RNA degradosome. Despite the lack of internal membranes, bacterial machineries involved in transcription, translation and RNA processing are separated spatially. The first aim of this project is to explore t
The cellular trafficking of Fe-S clusters in plants – Fe-S traffic
Maturation of iron-sulfur (Fe-S) protein requires de novo synthesis of Fe-S centers onto scaffold proteins and their transfer to target apoproteins. The objective of this project is to characterize the molecular mechanisms of Fe-S cluster transfer in mitochondria and chloroplasts via the NFU and ISC
Choreography of Chromatin Domains Across Cell Types: Reshuffling Replication Profiles and Common Fragile Sites – FRA-Dom
Common fragile sites (CFSs) are megabase-long loci characterized by conventional cytogenetics as regions prone to breakage in cells submitted to replication stress. The interest in CFSs stems from their key role in promoting DNA damages and genetic alterations associated with neurological disorders,