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Lanthanide complexes as Trojan Horse for proteins structural studies – Ln23
The objective of the project is to design lanthanide-based coordination complexes for the determination of protein structures using three complementary techniques: X-ray diffraction, SAXS (Small Angle X-rays scattering) and NMR. This requires finding a family of lanthanide complexes that is (i) stab
Catalyst activation driven by photoinduced electron transfer – PET-Cat
Considering transition metal catalysts, generation of a highly active catalytic species on demand by light irradiation of an inactive precatalyst presents several key benefits, particularly for large batch synthesis : 1) handling metal species that are stable under ambient conditions; 2) switching “
Enantioselective synthesis of furan and pyridine atropisomers by central-to-axial chirality interconversion – SynthAx
The SynthAx project deals with the chirality control of complex atropisomeric molecular scaffolds by central-to-axial chirality conversion. Our innovative approaches are built on enantioselective catalysis for the control of central chirality coupled with an oxidative aromatization revealing the axi
Covalent crystalline organosilica networks – CrystOS
Organosilicas are a class of materials combining a silicate lattice and organic substructures and are generated by simple hydrolysis-polycondensation of functionalized molecular precursors. These materials, which have a great potential in terms of properties associated with their chemical compositio
Chemical tools for the modulation and monitoring of protein-protein interactions at the synapse – ChemMoPPI
The general aims of the project are to elaborate innovative chemical tools that will enable us to circumvent current technical hurdles in order to investigate specific protein-protein interactions and to implement these tools to address fundamental questions pertaining to the internal dynamic organi
Mixed-valent bis(µ-oxo)CuIICuIII in C-H bond activation – COMEBAC
Methane is a greenhouse gas that remains in the atmosphere for approximately 9-15 years. It is over 20 times more effective in greenhouse effect than carbon dioxide over a 100-year period. Methane is also a primary constituent of natural gas and an important energy source. To reduce its greenhouse g
Organic Synthesis with Zeolites – CHOZE
Organic synthesis, especially multi-step synthesis often relies on numerous stoichiometric and toxic and/or hazardous reagents. In order to ease handling and mostly purifications, reagents as well as neutralizing or scavenger agents have been grafted to organic polymers, leading to the so-called sol
Heteronuclear manganese/calcium complexes as models of the Oxygen-Evolving Center of Photosystem II: an experimental and quantum chemical investigation of their physical properties and reactivity – MnCaOEC
The oxygen – evolving – center (OEC) of photosystem II which catalyzes the four electrons oxidation of water into dioxygen is an inorganic oxygen-bridged cluster of four manganese and one calcium ions (Mn4CaO5) and stabilized by carboxylate ligands. The water oxidation mechanism at the molecular lev
Design and synthesis of antibody mimics – Mimobody
The monoclonal antibodies (mAb) constitute a therapeutic alternative to treat tumours. Several barriers remain to overcome for their optimal exploitation in particular their low capacity to reach the solid tumours (150 kDa), their immunogenic character, their mode of biological preparation, and thei
Preparation of Carbo- and Heterocycles via novel Environmentally Friendly Radical Processes. – UZFUL-Chem
5- And 6-membered carbo- and heterocycles are present in a plethora of molecules of biological interest and hence, they are attractive targets for organic chemists. Among the methods available for their preparation, the use of radical intermediates is of particular interest. Carbon–carbon bonds can
Lewis acids: acidity scales and catalytic activity – ALEA
The ALEA project involves two research groups at the University of Nice, one specialised in organic synthesis and catalysis and the other one in physical organic chemistry. The project deals with synthetic and physicochemical aspects of catalytic reactions with Lewis superacids, which have shown to
Novel peptoid architectures: from structure to biological function – ArchiPep
The design of folded artificial molecular architectures capable of mimicking structures and functions of biopolymers is a field of research which has rapidly expanded over the past fifteen years. A wide range of abiotic backbones have been developed including, aliphatic and aromatic oligomers, homog
Effect of Light Irradiation on Spin Crossover Single Ion Magnets Involving Redox-Active Ligands – SCOSIMLIGHT
It clearly appears that the molecules will be used as basic component in the electronic of tomorrow. Since they are the smallest stable structure, they are the final objective for the miniaturization of the electronic circuit. The chemists can selectively design molecules with specific properties fo
Bistable hybrid nanostructures – NanoHybrid
This project emerges at the crossroads of several new ideas based on our recent results, which were obtained in the frame of different national and international projects arriving to their final stages. At present, we possess a unique know-how at the international level in the synthesis of spin cros
Bisubstrate and prodrug approaches for the rational design of new DXR nhibitors: Novel antimicrobial and antitubercular drugs – ANTITUB
Proteins involved in isoprenoid biosynthesis represent such targets. Isoprenoids are found in all living organisms and are essential for all bacteria. The alternative mevalonate-independent methylerythritol phosphate (MEP) pathway for the biosynthesis of isoprenoids, which is present in many pathoge
Synthesis of aminoacyl-tRNA analogues to explore non-ribosomal peptide synthesis in bacteria – MimictRNA
The major focus of the present proposal concerns the catalytic mechanism of FemX, a representative of the tRNA-dependent transferases involved in peptidoglycan synthesis. The first substrate of this enzyme, UDP-MurNAc-pentapeptide (UM5K) is a composite structure including a carbohydrate, a nucleotid
Hybrid organic inorganic liquid crystal materials containing luminescent transition metal clusters – CLUSTOMESOGEN
The CLUSTOMESOGEN project aims to synthesize and study functional liquid crystal containing metallic clusters as luminescent inorganic dyes in the Red-NIR area. These studies will orient the design of devices demonstrating the high potential of such materials in optic and optoelectronic applications
Hybrid Open Porous Frameworks as Artificial MetalloEnzymes – HOPFAME
HOPFAME vision: We believe that functional porous coordination polymers (PCP) can be used as model materials for mimicking enzymes. The well organized structure of PCP and softness shall enable the modeling/understanding of molecular recognition properties. The successful use of chiral PCPs for ste
New evaluation of electronic effects of ligands bound to a metal by mass spectrometry – EELEM2
The project submitted here focuses on organometallics reactivity studies conducted by our group with the help of mass spectrometry and in collaboration with solution chemistry experimenters and theoretical chemists. Its ambition is to be the starting-point of the creation of a national research netw
Supramolecular catalysis based on dynamic hydrogen-bonded assemblies – SupraCatal
Intense research efforts are made towards the discovery of innovative catalysts. Among the strategies used, supramolecular catalysts are investigated with the aim of modifying the second coordination sphere of a metal center; an unsolvable challenge with classical covalent metal-catalysts. Up to now
The adventure of hemicalide: Total synthesis, design of analogues and biological evaluation – AMICAL
Natural product play an important role in cancer chemotherapy and the discovery of compounds possessing a new mode of action represents an important challenge to overcome the problem of resistance and current drugs inefficacy. Hemicalide is a new natural product isolated from extracts of the marine
Artificial Molecular Architectures Mimicking Photosynthetic Z Scheme – MolecularZScheme
Most of the energy found in the biosphere derives from the natural photosynthesis process. Mimicking this fundamental biological process represents a fantastic scientific challenge because it opens the possibility to produce fuels from sunlight at large scale with abundant and cheap raw materials su