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Towards a photo-herbicide: synthesis and studies of water-soluble fluorescent tagged porphyrins, from solution to plant cells – PorphyPlant
In connection with current environmental concerns, the aim of this project is to develop soft agronomic practices taking into account the environment without decreasing agricultural efficiency. In this context, our project is to design molecular systems based on porphyrin patterns, which are molecul
New stablilized Radicals for new applications – NewRaP
In our industrialized society, many applications are based on magnetic materials. These products impact all sectors of our economy. One challenges in the field of magnetic materials research remains the preparation of organic magnets. They are lighter, more flexible, and less energy intensive to mak
Gold Catalysts for Organic synthesis – AuCat
Considering the limited number of catalytic systems presently available and the fact that those are not always optimal in terms of efficiency, selectivity and stability, the aim of the current proposal, is to: 1- to develop a series of various new catalytic systems that could complement or improve t
Coupling of Phenols and Indoles towards benzofuroindolines analogs of diazonamide A. – CouPhIn
Diazonamide is active in vitro and in vivo against various cancer cells via an unprecedented mode of action. Unfortunately, this compound is scarsely available in Nature and its chemical synthesis is too long. Therefore, our goal is to build simplified analogs of diazonamide and evaluate their antic
Development of antitumoral multiantigenic synthetic vaccines – VacSyn
Despite recent progresses in prevention, diagnosis and treatment, cancer remains the leading cause of death worldwide. To fight against this disease, recent studies have shown that immunotherapy is a very good alternative to traditional treatments whose side effects are still intolerable today. In t
Multi-component Assembled Architectures incorporating CO2 for Selective Capture of Rare Earth – MA2RCO2SCARE
Multicomponent Dynamic Combinatorial Chemistry is an innovative strategy that we currently develop. It can easily deliver adaptative systems displaying high degrees of selectivity in terms of molecular recognition. In that perspective, we have recently designed CO2-induced self-assembling systems, w
Original Gold-Alkyl complexes for coordination-insertion polymerization of olefins – POGO
we propose in this project to prepare original bidentate Au(III)-alkyl complexes for their investigation in coordination-insertion polymerization of olefins. At this stage of the project, we have developed a new synthetic strategy for the straigthforward preparartion of stable gold(III)-alkyle compl
The 5-hydroxyfuran-2(5H)-one a useful platform molecule for development of new organocatalytic asymmetric one-pot reactions. – HFOrgCat
The development of new synthetic pathway leading to enantiopure compounds with significant structural diversity is an ongoing challenge in many fields of chemistry. The efficiency of these processes has to be evaluated, not only in term of quantitative criteria, such as yields and/or optical puriti
New Inverse Peptide Synthesis Strategy – NIPS
Peptides are attracting increasing attention not only as therapeutics (about 60 peptide drugs are on the market) but they have also been studied and used for other promising applications, some of them associated to polymer or material sciences: artificial silks, hydrogels, supported catalysts, targe
Bio-inspired oxidation catalysts : towards environmentally friendly chemistry – BIOXICAT
The main objective of this proposal is the development of catalytic systems able to perform selective oxidation directly using molecular oxygen in water under mild conditions. The current industrial processes for such reactions require harsh conditions, associated with strong oxidants and potentiall
New chiral acids for catalysis – NeoACat
The main objective of the synthetic organic chemist is to propose innovative and efficient solutions to chemical molecules synthesis. Indeed, the growing demand from pharmaceutical industry in terms of molecular complexity to develop more efficient and selective drugs led to revisitate traditional c
Multi-Active Ligands for Alzheimer's Disease – MALAD
Because the pathogenesis of AD is complicated and related to the abnormality and dysfunction of multisystems, there has been no ideal drug for preventing and treating AD till now. The goal of current treatments is to improve neuronal dysfunction and produce only symptomatic benefits and drugs that a
Development of a glycoconjugate vaccine against melioidosis – MELIVAC
Burkholderia pseudomallei (Bp) is the causal agent of melioidosis. The high infectivity of the bacteria via the human respiratory system combined with high mortality rates and resistance to antibiotics make this category B agent a suitable target for use as a biological warfare by terrorists. Experi