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A library of fluorescent probes to study Reactive Oxygen Species At the Single cell level – ROSAS
Billions of years of photosynthesis have resulted in an oxygen-rich atmosphere in which the respiratory chain and aerobic life could evolve. This allowed the apparition of so-called “superior life forms”. However, the use of oxygen as an electron acceptor results in the concomitant formation of part
design of potential antiMAlarial M1/M17 AMinopeptIdase Agents – MAMMAMIA
The situation is worrying as in most parts of the world, Plasmodium resistance rendered ineffective older low cost (average $ 0.37) antimalarial drugs (quinine and chloroquine),To fight against the emergence of resistance, the World Health Organism now recommends the use of drugs combination therapi
Quinolinate synthase, an iron-sulfur protein as a key target for the design of antibacterial agents – NADBIO
The nicotinamide adenosine dinucleotide (NAD) is synthesized in all living organisms from quinolinic acid (QA). However, the biosynthesis of QA differs between organisms. In eukaryotes it is produced via the degradation of tryptophan whereas in prokaryotes it is synthesized via two enzymes: L-aspart
A new Generation of dRugs for ALzheimer’s disease based on in vitro and in silico experiments of beta-amyloid oligomers and in vivo tests – GRAL
The GRAL project, which integrates different and complementary expertises from chemistry, biophysics, structural biology, computer simulations, in silico design and screening of compounds to transgenic flies and mice, aims at discovering efficient therapeitic agents against Alzheimer's disease. We c
Diphosphine Nickel (0) : one metallic fragment for three applications – DiPhoNi
Possible associations between a metal and ligands are countless, which allows a fine tuning of the reactivity at the metal center. It permits the formation of novel molecules via bond forming processes. We are interested here in the development of three applications: cross coupling reactions, CO2/al
Triple bond alumination: a general synthesis of aromatic and heteroaromatic organoaluminum compounds – TriBAl
Organometallic compounds are reactive species classically used in synthesis. However, their high reactivity is also a problem when manipulating molecules with a large number of functions. One of the current issues of the chemistry of these compounds is to modulate the reactivity of their carbon-meta
Cobalt-Catalyzed Bond Activation Coupled with Light-induced Functionalization – CoCaCoLight
For the last twenty years, researchers have paid much attention to the ecological and economic significance of chemistry. Thus with respect to the principles of green chemistry, a strong development of homogeneous catalysis has taken place to reduce waste and energy costs. Among the broad range of t
Magnetic bistability in new molecular systems based on bridging anionic ligands – BISTA-MAT
The BISTA-MAT project, gathering four complementary groups which are recognized in their respective fields (Brest: Partner 1, Nancy: Partner 2, Bordeaux: Partner 3 and Versailles: Partner 4), deals with molecular bistability which is, undoubtedly, one of the most searched properties in molecular mat
Hybrid hierarchical catalytic structures for synthesis of biofuels – CATSYN-BIOFUEL
-Design of new hybrid bifunctional catalysts with three levels of porosity (micro, meso and macro). - Optimization of heat transfer using a ceramic matrix with a high thermal conductivity; - Improved catalyst stability, in particular in the presence of sulfur and other impurities biosyngas. -New
Total synthesis of polyketides exploiting bioinspired cyclizations: hirsutellones and chalasin related compounds – SYNBIORG
The SYNBIORG project will be divided into 4 tasks. The bio-inspired linear precursors of the natural products (hirsutellone B, talaroconvolutins et périconiasins) will be constructed and methodologies will be developped for that purpose (Task 1). The chemical reactivity of these precursors will then
Neutral radical gold dithiolene complexes as Mott insulators for information storage – GOLD-RRAM
Our project has the ambition to tackle the two following issues associated with the stimulation of molecular Mott insulators by chemical or physical pressure, by chemical or gate voltage doping or by electric pulses: • How can we enhance the conductive properties of rho = 1, full charge transfe
Identification of proteins responsible for iodide capture in the thyroid gland – ChemBiode
Although many efforts have been made to characterize the mechanism of iodide transport and its regulation at a cellular level, only very little is known. This project aims at dissecting the cellular pathways implicated in the capture of iodide in thyroid cells.Such a discovery will open promising pe
Bioinspired catalytic CO2 reduction – CarBioRed
The CarBioRed project aims at designing efficient and selective non-noble metal based catalysts for CO2 electro-reduction. It thus meets the societal issues related to the reduction of greenhouse gases and to the development of renewable energy sources in place of fossil fuels. Our choice in the m
Investigating the Role of Molecular Recognition Dynamics in Weak Protein-Protein Interactions – ComplexDynamics
A complete description of biomolecular activity requires an understanding of the nature and the role of protein conformational dynamics. In recent years novel nuclear magnetic resonance (NMR) techniques have emerged that provide hitherto inaccessible detail concerning biomolecular motions occurring
Programmed Molecular Systems for the Double Targeting of the Tumor Vasculature – ProTarget
Current cancer chemotherapy is not effective against many common solid tumor types. Most anticancer drugs act by anti-proliferation mechanisms and lack any intrinsic antitumor selectivity. In turn, chemotherapy is frequently associated with severe side effects due to the destruction of normal tissue
Hierarchical supramolecular Architectures – Supra-HierArchi
Our aim is the development of a new tool kit allowing to prepare in aqueous solution and in high yield individual fibrilar objects of perfectly controlled cross-section, by bundling of a predetermined and adjustable number of primary rods through cyclodextrin functionalization. Preliminary studies o
Pi-Radicals as Building Blocks for Electron-Responsive Molecular materials and Organized Assemblies – PRIMO
The ability to control the organization of molecules within molecular materials has emerged in the past decade as a major scientific objective that is mainly motivated by exciting foreseeable applications in areas ranging from electronics to materials science. The main objective of this project is t
alpha-Aminoperoxides: from titanium chemistry to complex nitrogen-containing molecules – ACTiMAC
Our main goal is to combine the power of the Kulinkovich-de Meijere cyclopropanation reaction with the synthetic potential of alpha-aminoendoperoxides, to develop original chemistry and discover novel methods for the expedient construction of complex nitrogen-containing systems. These methods are in
Luminescent zinc fingers: toward lanthanide-based near-infrared optical sensors for biological imaging of zinc – LUMZIF
The main objective of the LUMZIF project is to develop Zn2+ selective probes for biological imaging of zinc. We aim at synthesizing probes that (i) selectively detect Zn2+ over other physiological cations, (ii) emit in the near-infrared window where (a) where light scattering is also reduced and (b)
Polyhydride IRON complexes and HYdrofunctionalized Catalysis – IRONHYC
Goals: substitute the expensive and toxic transition metals currently used in homogeneous catalysis by cheap and eco-friendly ones such as iron. The corner stone of the project is the development of active iron complexes in hydrofunctionalization reaction. Objectives: i) the development of a l
Redox modulation of luminescence : association of ruthenium organometallics and luminescent units – RuOxLux
The aim of the project is to develop novel fundamental issues for optically switching molecular materials, with a rarely used strategy based on electro-modulation of luminescence. Electro-modulation of luminescence combines several advantages over other types of modulations: contactless photo-activa
Sequential 1,6/1,4-Asymmetric Conjugate Addition and Tandem Enolate Trapping: Applications in Total Synthesis of Natural Products – SCATE
The production of new enantio-enriched molecules remains an important scientific challenge both at academic and industrial levels. The production of tomorrow’s drugs requires new synthetic methodologies, particularly when stereogenic centers need to be formed. Nowadays, transition metalbased asymmet
Cationic Boranes and boronic compounds: New tools for fluorination and radiofluorination – BoBo
Fluorine is found in a range of API and is also used as a probe in medical imaging, especially as its radioactive isotope. A wide array of methods of fluorination has been developed recently. Yet their mass efficiency is usually low. Moreover these fluorination agents are scarcely recyclable. Our
Multifunctional metal-based helicenes derivatives – MetalHel
In the MetalHel project we propose to prepare a great variety of [n]helicene ligands bearing the appropriate functional moiety that will serve for binding to the metal ion. i) Helicenes bearing phenyl-pyridine chelates will enable to prepare monoplatinated(iridated) and bis-platinated(iridated) he
Use of superacid conditions to highlight unprecedented transient intermediates in glycochemistry – OXYCARB
So-called glycosylation reactions enable sugar activation and are therefore a necessary step in the creation of sugary chemical compounds with novel functions. This life-essential reaction has been studied and chemically exploited for over a century even without full understanding of the mechanism b
Study of Reactive Unusual Sulfur Heterocyclic Intermediates – SUSHI
Notre projet propose d’étudier la formation de composés très réactifs peu exploités jusqu’à présent comme des bétaïnes, des diènes cisoides, des thioaldéhydes ou des 1,3-dithietanones et d’investiguer leur potentiel synthétique. Des applications de ces méthodologies sont envisageables en synthèse to
Click strategies for multifunctional anti-Alzheimer agents – Multi-click
Alzheimer’s disease, which is the most common cause of senile dementia, is a major public health issue. AD is a multifactorial disease, and all the tratments aiming only one biological target failed. Scientific cimmunity thus turned towards a multi-targetdirected ligands strategy. In this context, t
Antiviral compounds via in situ RNA-click chemistry – ClickEnARN
An essential RNA sequence involved in the replication cycle of HIV was discovered in 1994 in Strasbourg. This sequence, the initiation dimerization site of HIV-1 genomic RNA is crucial for HIV and could be a prime target in the context of a new anti-HIV therapy. The objective of this project is to
BIsmuth BIfunctional CHElates for Medical APplications of alpha-emitters: design, synthesis, and radiolabelling – BIBI-CHEMAP
Large tumor masses may be currently treated with beta emitters vectors such as yttrium. However, such vectors are not suitable at all for the treatment of diseases related to isolated and / or circulating cells. For these conditions, it is indeed necessary to use alpha emitters, exhibiting a higher
New supported metal oxides : toward understanding of industrial catalysts for olefin metathesis through a combined synthetic, 17O NMR and DFT approach. – OXOCAT
Owing to the strategic importance of olefins as building blocks for the world chemical industry, development of efficient alkene metathesis processes is of utmost relevance. In this context, tailored heterogeneous catalysts with known structure-activity relationship may improve lifetimes and activit
Re-designing proteins using Foldamer chemistry : Synthesis of artificial zinc fingers, folding and nucleic acid binding properties – FOLDART
The purpose of the FoldArt project is to explore the chemical synthesis, folding, and function of composite proteins created by substituting one or more a-helical regions of a target protein by one or more non-peptide helical segments (urea-based foldamers). The development of sophisticated folded a
Resorcinarenes for intra-cavity catalysis – RESICAT
The aim of this program is to produce catalytic reactions taking place inside a molecular cavity. Homogeneous catalysts operating in cavities or containers exclusively made of covalent bonds have not been reported to date. This project involves the use of a specific class of macrocycles, namely reso