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Immunostimulating molecules with a broad-spectrum antiviral activity: a proof of concept in non-human primate models – STING-2.0
Our therapeutic arsenal to treat virus-infected patients is extremely limited, and there is a critical need for broad-spectrum antiviral molecules that could be used against multiple viruses. Among possible strategies, the idea of molecules stimulating the innate immune response in host cells is of
An immuno-modulatory phosphorus-based dendrimer for the treatment of Multiple Sclerosis – DENDRI'MS
Multiple Sclerosis (MS) is a Chronic Inflammatory Disease (CID) of autoimmune origin. It is the commonest neurodegenerative disease within the young adult population. Indeed, MS affects 2 million persons worldwide, essentially women. Although efficient treatment have been introduced at the beginning
Tools for Tissue Quantification by Imaging: High Content Histopathology of human and artificial tissues – TooTiQuantI
Quantitative cell biology based on image analysis underwent a very important development in the recent years, allowing the birth of tools adapted to an industrial use in the field of drug discovery. This industrialization of “cell biology by imaging” is coined “High Content Analysis” (HCA) or “High
Lead generation of original anti-malarial compounds : a synergetic multi-targets approach – MaPI
Malaria is the most important human parasitic disease and a major public health concern. Since 2007, an ambitious goal of malaria elimination and eventually eradication has been set, control interventions have been scaled up and malaria cases have declined. Yet, there were still 220 million malaria
TrophoTest , a new non-invasive approach to prenatal diagnosis using in vitro culture of trophoblasts isolated from maternal blood – TROPHOTEST
Prenatal diagnosis includes a screening phase which must be considered by ethic regulatory and a diagnosis phase which are invasive procedures such as collection of trophoblasts or amniocentesis, which include for each of them, risk complications for mother and fetus. The risk of fetal loss is estim
Discovery of druggable protein kinases in the protozoan parasite Leishmania donovani using hit compounds identified by phenotypic screening – TRANSLEISH
The protozoan parasite Leishmania donovani causes fatal human visceral leishmaniasis, one of the most neglected tropical diseases. In the absence of economic incentive, serious Research and Development (R&D) investments into anti-leishmanial drug development lack from the portfolio of the major phar
Preclinical development of Dendrogenin A, an innovative molecule with an original mechanism of action, for the treatment of Acute Myeloid Leukemia – DAML
Acute myeloid leukemia (AML) are the most widespread acute leukemia in adults. Despite a high rate of complete remission after treatment with genotoxic agents (anthracyclines and Ara-C), relapse rates are very high resulting in a poor outcome in most cases (40 % overall survival in younger adults, 1
Humanized Immune System mouse model for developing new therapeutic products and preclinical evaluation of vaccine and monoclonal antibodies candidates. – ImHIS
There is a critical need to screen and validate new vaccine candidates as immunotherapies for cancer, infection, and autoimmune disease. Recently, Human Immune System (HIS) reconstitution in immunodeficient mice has received renewed interest as a means to unravel the physiopathology of immune-relate
Preclinical assessment of HEMO2life® supplementation for marginal kidney preservation: comparison between static cold storage and machine perfusion – HEMO2Perf
Solid organ transplantation has become an accepted and viable treatment option for end-stage organ failure. Over one million people worldwide have had their lives saved or their quality of life improved by an organ transplant. However, the number of organ donors has been falling for at least a decad
Securitized production of adipose-derived stromal cells for cell therapy – SAFE
In recent years, relevant data have indicated that mesenchymal stroma/stem cells (MSC) can be used as reparative/regenerative cells to treat a broad range of clinical conditions including immunological implications as well as degenerative situations, creating a great hope to treat a wide range of pa
New microscopy techniques for 3D super resolution imaging – TRIDIMIC
Our understanding of living matter requires measurement tools having an increasing accuracy and, at the same time, sufficient speed, robustness and reliability so that a large number of conditions can be screened in a reasonable time. This notion of screening is essential to finding new drugs and al
Large scale platelet production from stem cells in microfluidic devices – PLASMIS
Platelets are essential to stop bleeding after vascular injury and to prevent hemorrhage. Patients with chemotherapy, bone marrow transplant or polytrauma display low platelet counts and require platelet transfusions. The only source of platelet concentrates (PC) comes from blood donors. However, st
Drug discovery from venoms using miniaturized artificial bilayers – VenomPicoScreen
The endpoint of the VenomPicoScreen project is the identification of new drug candidates acting on ion channels and receptors from venom peptides. To achieve this goal, we propose to develop a membrane protein platform for the screening of nanoliter volumes of venoms, enabling assays based on a sing
A parasite enzyme as a new therapeutic agent in Inflammatory Bowel Diseases – ACROHNEM
The present project (ACROHNEM: Anti CROHN Enzymatic Molecule) aims at the development of a well- characterized parasite protein as a new therapeutic agent in dramatically increasing Inflammatory Bowel Diseases (IBD), with a particular focus on childhood onset Crohn’ s disease(CD). The increase
Innovative protein therapies for retinal diseases – Innovision
Age Related Macular Degeneration (AMD) is the first cause of social blindness in the elderly population. Wet AMD resulting from the abnormal growth of neovessels originating from the choroids towards the retina, complicates about 40% of all AMD and choroidal neovascularization (CNV) induce 90% of s
Towards a global vaccination approach against multi-resistant staphylococcus aureus targeting the cellular, humoral and innate arms of the immune system – MRSA-VAC
Context. Methicillin-resistant Staphylococcus aureus (MRSA) is at present the most commonly identified antibiotic-resistant pathogen in many parts of the world. MRSA infections represent a major Public Heath issue with important impacting socio-economical consequences. Several prophylactic and thera
Production, purification and selection of second generation recombinant antithrombins of therapeutic interest : applications to severe sepsis and extracorporal circulation – THERAT
Antithrombin, a double agent, anticoagulant and cytoprotective : The THERAT project the coagulation inhibitor, antithrombin (AT). In addition to inactivate thrombin (factor II activated or factor IIa of coagulation) that converts fibrinogen into fibrin, AT physiological role is much broader: this pl
Optimized antigens for a new lentivirus vaccine strategy – LENTIxIS
The Research Unit UMR8122 led by the Project Coordinator has identified within the envelope protein of oncoretroviruses a domain endowed with immunosuppressive properties (IS domain) assessed in vivo using a test of inhibition of the immune response in mice: expression of this functional domain by t
Microfluidic platform for cell culture, in vitro construction of complex neuronal networks and the screening of neuroprotective molecules – Neuroscreen
This proposal is based on interdisciplinary work that combines microfluidic and nanobiophysics technologies developed at Curie Institute (team ofL. Malaquin/JL Viovy) with fundamental neuroscience methods and experimental models developed in the team of B. Brugg/JM Peyrin at Université Pierre et Ma
Translational development of an innovative immunotherapeutic biological drug for treating cancer. – TransTherapeutic_ImmunOnco
This translational and industrial program aims at positioning an innovative immunmodulatory agent, an improved and recombinant fusion IL-15 protein called CYP0150, to treat cancers in the best conditions. Based on a strong basis of relevant in vivo models (human immune system mouse, primates) and ex
Innovative treatments for septicemia – Septiscreen
The incidence of sepsis is continually increasing, with 300 cases per 100,000 per year in the US. Mortality is still in the order of 30-50% resulting in 800,000 deaths per year in the US. In most cases the pathogens involved are sensitive to commonly used antibiotics but treatment is insufficient du
Research Work Combining Vector and Stem cells for Treatment of Ischemia – TRAVESTI
The vascular network is a fundamental component for an organ because it allows the delivery of all molecules necessary for its metabolism (nutrients, respiratory gases, growth factors and endocrine, etc.) and thereby under-perfusion leads to many chronic diseases. For some, ischemia is directly the