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New models and development of biomarkers for human placental toxicology applied to environmental polluants (benzo(a)pyrene and phthalate (MEHP)) – PLACENTOX
Exposure to environmental chemical contaminants may lead to adverse effects on human pregnancy and fetal development. The toxics under suspicion may act directly on the fetus but also via their effects on the placenta which is the interface structure between mother and fetus whose exchange functions
Effect of BPA in various mammalian developing gonads – MECABPA
During the last decade, concerns about changes in the environment and their possible consequences on the human and animal reproductive function have increased. For both males and females, several arguments suggest a link between environmental pollutants and alteration of the reproductive health. Amo
Numerical simulator for the accumulation by crops of inorganic trace elements contaminants of soils – SIM TRACES
Soil contamination by metallic trace elements (MTE) is a major concern because many MTEs are toxic to living organisms at very low concentrations. In general, human beings are exposed to these contaminants through food consumption because MTE are taken up from soil by food and feed crops. Currently,
Bacterial degradation and environmental impact of carbon nanotubes – DECANO
Carbon nanotubes (CNTs) represent an emerging nanomaterial for a wide range of applications both in materials science and biomedicine. The increasing production of CNTs, their processing and eventual incorporation into new types of composites and/or into biological systems has raised fundamental iss
In Depth characterization of HC-degradation CAPAcities of marine sediment microbial communities: adaptation, metabolic processes and influence of oxyGEnation regimes – DECAPAGE
Coastlines are subjected to a variety of pollution injuries from both sides, from the sea, predominantly by crude oil from shipping and offshore mining and from the land, principally through agricultural practices, urban waste waters and industrial activities. Hydrocarbon compounds and crude oil der
Impact Assessment of Genetically modified plants on the associated microflora and virus using a high throughput metagenomic approach – IMA-GMO
The current research project aims at better evaluating the consequences of the growth of GM plants on the associated microflora, bacteria and plant viruses, the transgenic DNA being considered as a potential contaminating agent of the ecosystems. A major interest of the project is to propose investi
Biosensing, toxicity and stability of ZnO quantum dots – NanoZnOTox
In the course of the NanoZnOTox project, we evaluated the impact of zinc oxide nanoparticles surface chemistry on their stability (photo-physical and physical) and on their toxicity towards bacterial cells. Our results show that when the particles are used at low concentrations, they decompose in aq
Developmental, behavioral, cellular and molecular evaluation of a embryo-fetal and juvenile toxicity induced by the chronic exposure during gestational and lactational phases to a mixture of the 6 NDL-PCB indicators in a mouse model – NEURODEVETOX
The raise of anthropogenic activities has led to a large release of various chemicals in the environment. These pollutants can affect the animal and human health via food chain contamination. Actually, epidemiological studies reveal a significant raise of mental and neurological disorders among chil
Impact of chlordecone in active chronic hepatitis progression – HEPATOCHLOR
Infectious disease and environmental health have been intertwined in the studies of public health during long time, however since several decades of years the fields of environmental health and infectious disease have diverged in many countries where these fields are currently treated as distinct en
Genotoxicity, IMmunotoxicity and rEprotoxicity of pesticides in Crassostrea gigas – GIMEPEC
The project « Genotoxicity, IMmunotoxicité and rEprotoxicity of PEsticides in Crassostrea gigas » (GIMEPEC) aims to study the rule of chemical contamination of coastal waters in oyster mortality outbreaks observed these last years in France. The previous results obtained within the MOREST project an
Role of the cellular environment and inflammation in chemical-induced allergy – Allergochem
Allergies are an integral part of our industrial society to such an extent that the OMS has classed them as the 4th important pathology in terms of morbidity. Further to this they have been in constant progression for the past 20 years, such that they have become a prominent threat to public health.
First study in France seraching a link between Amyotrophic Lateral Sclerosis and BMAA’s cyanotoxin – BMAALS
Abstract The main objective of this project is improve significantly the scientific knowledge about the possible link between amyotrophic lateral sclerosis and the cyanotoxin L-BMAA. Members of the consortium proposing this project are members of a network supported by INSERM (AAP RRC SP) for "a
Mercury Isotopes Fractionation and Notch/apoptosis biomarkers: a new link between Environment and Health – RIMNES
Mercury (Hg) is an important pollutant distributed all over the world, in the atmosphere, onto continents and inside oceans. It can be accumulated and bioamplificated in aquatic food chains where concentrations of its main toxic form, monomethylmercury (MMHg), reach level potentially dangerous for h
Cosmopolitan fungi: tools for bioremediation of contaminated soils – MycoRemed
A growing proportion of xenobiotics of anthropogenic origin are contaminants of natural environments, in particular in soils. The use of microorganisms is a promising strategy for bioremediation of contaminated environments. Although bacteria are the most common group of organisms used for bioremedi
Modelling of isotope effects measured by quantitative NMR in the monitoring of soil contamination by gasoline-derived pollutants – ISOTO-POL
Better methodologies appear to be necessary for detecting the origins of given pollutants, and for understanding the natural processes involved in their migration routes, biodegradation and eventual disappearance. In addition, it is essential to check whether treatment leads to complete mineralizati
Potential Toxicity of pesticides in Continental Aquatic Environments – PoToMAC
POTOMAC project brings strong innovation regarding new passive sampling strategies coupled with chemical and biological analyses. Initially, this project aims to develop a range of passive samplers to characterize the contamination levels of surface waters by diffuse pollution from agriculture. Acco
Variability-adaptation-diversity and Ecotoxicology in Gammarids – GAMMA
Ecotoxicological hazard assessment of chemicals for aquatic ecosystems could be implemented via either a priori approach, with toxicity evaluation of a new compound before its use, or a posteriori approach, with the development of chemical and biological tools for quality assessment of aquatic ecosy
INTERCONNexions between terrestrial and aquatic bioaccumulations of organometalic compounds in food webs – INTERCONNECT
Mercury is a natural compound of the terrestrial crust and can be emitted in the environment but various anthropic sources can be added to this natural source. According to the United Nations Environment Programme (2003), industrial activities would be responsible for more than 70% of the atmospheri
Effects of chlordecone (Kepone) contamination on epilithic biofilm in rivers: identification of elements of bioindication – CHLORINDIC
Significant contamination by pesticides in some freshwater resources has been highlighted at the beginning of the 2000’s in Guadeloupe and Martinique Islands (French West Indies). Though they were banned from usage in the 1990’s, toxic and persistent molecules are still present in soils, with concen
Cellular, molecular and genomic investigation of chronic environmental exposure of low doses pollutants in a tumor progression model of breast cancer – CLARENCE
As growing evidence indicates that exposure to environmental carcinogens may increase the risk of sporadic breast cancers, it is of most importance to decipher the role of environmental carcinogens in the chronic carcinogenesis of human breast epithelia and their contribution in the development of t
Chemical, microbiological, spatial characteristics and impacts of contaminants from urban stormwater detention basins : Assessment and Management of Environmental and Human Health Risks – CABRRES
Urban storm waters are known to be polluted by metallic toxic elements, PAH, pesticides and many other toxic molecules. These substances are mainly transported by suspended solids which can then contaminate receiving bodies. The growing knowledge on the ecotoxicological risks and human health hazard
The fate of metal elements in arctic and sub-arctic areas: ecosystems and northern populations exposure – Arctic Metals
Our knowledge of the behavior of metals in the environment is critical for a number of social issues, namely economic, regulations, health of living organisms and humans, traditional way of life. The Arctic Metals project aims at developing tools (speciation, isotopes) to assess metals sources, mobi