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Cellular control of retroviral integration selectivity – RetroSelect
Gene therapy aims to correct the expression of a defective gene by insertion or replacement of an active copy of the gene. For optimal long-term expression of this active copy, its insertion inside the genome and the stability of the integration locus is important. To be efficient the transgene must
Molecular basis of immune tolerance after gene transfer – Gene_Transfer_Tolerance
Gene therapy treatments of various metabolic diseases and genetic disorders consist of vectorization of therapeutic transgenes in specific target tissues, such as microdystrophine in muscles of patients with Duchenne Muscular Dystrophy. This approach is based on de novo expression of a functional pr
Functional genomics through transposon-mediated mutagenesis to unravel virulence gene regulation in Plasmodium falciparum – PlasmoPiggyBac
Despite major efforts of several laboratories, the molecular mechanism of antigenic variation in P. falciparum remains puzzling due to its complexity. It has been shown that a repertoire of different molecular regulatory mechanisms plays a role in monoallelic var gene expression (genetic var element
Comparative analysis of signal transduction factors controlling cell cycle regulation in the alpha-proteobacteria – CASTACC
Although the regulation in the two species is partially conserved, the model systems use different connections to control cycle of DNA replication and cell division. The circuit can be seen as a complex of modules that can be connected in multiple ways in order to give the oscillation of cell cycles
Molecular basis of signaling induced by Neisseria meningitidis on epithelial and endothelial cell – NeMeSi
Neisseria meningitidis (the meningococcus, Nm) is a common inhabitant of the human nasopharynx, and as such is a normal, saprophytic organism that is transmitted from person to person by direct contact. Appreciatively 3 to 30% of healthy human being carries this bacterium onto the nasopharynx. Nm ca
Tools for the genetic engineering of tghe malaria mosquito Anopheles gambiae – GEMM
Historically, vector control against the malaria mosquito has been the most efficient method to roll back malaria. Recent studies on the biological interaction between the vector and its parasite have shown that the mosquito immune system is usually able to eliminate Plasmodium, opening new perspect