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Construction of a composite surrogate marker of the long-term survival: application to kidney transplantation – CSM (Composite Surrogate Marker)
More than 250000 Europeans are living with a graft and 80000 people are enrolled in the waiting list. Given the limited availability of donor, it is of importance to improve graft survival. The goal of our proposal is to define an appropriate methodology to assess the prognostic capacity of a compos
Mlecular Deciphering Of Malignancy in Pheochromocytoma and Paranganglioma – MODEOMAPP
Pheochromocytomas (PHEO) and paragangliomas (PGL) are tumours that arise from chromaffin tissues of the adrenal medulla and sympathetic and parasympathetic ganglia. They are malignant in 15% of cases and hereditary in 30% of cases. Hereditary PHEO/PGL are caused by germline mutations in one of the 9
Role of Inflammation in the Pathophysiology of Neuropsychiatric Co-Morbidity in Obesity – OBEPSY
The prevalence of obesity over the world is reaching pandemic proportions. Not only related to an increased risk of metabolic and cardiovascular diseases, obesity is also associated with a higher incidence of neuropsychiatric symptoms, including emotional distress, mood alterations and cognitive dys
The Na+/H+ exchangers of intracellular compartments. Biochemical and pharmacological characterization. Physiological roles and impact in neurological diseases. – NHEINT
The acidification of intracellular compartments is critical for a wide range of cellular processes, such as protein maturation, degradation, receptor recycling and desensitization as well as neurotransmitter loading in synaptic vesicles. This acidification occurs through a steady-state mechanism th
Role of actomyosin system in normal and pathological megakaryopoiesis – MyoMeg
The maturation of megakaryocytes (MK), which leads to the formation of platelets, is a unique phenomenon characterized by three different processes: Polyploidization (MK become polyploid by a mechanism called endomitosis); the formation of proplatelets (at the end of differentiation, MK form cytopla
Inter-dependence of circadian oscillators along the hypothalamo-pituitary lactotroph axis. – Lacto-Clock
- - - - The misalignment between our internal timing system and the external environment can be the cause of dramatic consequences. This issue has become critical since the early 20th century, and the emergence of our never-stopping society, busy 24 hours a day. For example, most of the major indus
Identification of proteases involved in pathogenesis of inflammatory bowel disease, deciphering molecular pathways altered by their hyperactivity – IBD-ase
Inflammatory Bowel Diseases (IBD) are chronic inflammatory disorders of the gut, which are characterized by an uncontrolled inflammatory response to lumenal content. The main forms of IBD are Crohn’s disease and ulcerative colitis. Only palliative care is available to the several million patients af
Effect of sacral nerve stimulation on central and enteric nervous system – SacralNeurostim
Fecal incontinence is a distressing condition defined as the involuntary discharge of liquid or solid stools. Fecal incontinence is a worldwide public health burden with a prevalence of 2-15% in adult patients, resulting in a cost of more than $400 million per year in United States. The first step o
Basophils involvement in Systemic Lupus Erythematosus – BASILE
Systemic Lupus Erythematosus (SLE) is a multifactor-mediated disease affecting multiple organs that could lead to death when the kidney damage (lupus nephritis) is confirmed. Lupus nephritis is characterized by glomerular deposits of IgM, IgG and IgA autoantibodies-containing circulating immune comp
Autophagy : new therapeutic target in ALK-dependant tumors? – ALK-PHAGIE
The anaplastic lymphoma kinase (ALK) is an oncogenic tyrosine kinase involved in a still growing spectrum of cancers. First identified as the driver translocation in 80% of Anaplastic Large Cell Lymphoma (ALCL), its role in the pathogenesis of some B cell lymphomas, inflammatory myofibroblastic tumo