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Preclinical analysis of the efficacy of a LIM Kinase inhibitory compound for primary and metastatic cancer chemotherapy – LIMINIB
Tumor metastasis is the primary cause of death of cancer patients. Moreover, the emergence of drug resistant tumor cells substantially limits the clinical usefulness of drugs used in current chemotherapy. Development of new therapeutics effective against drug-resistant cancers and preventing tumor m
Preparation and in vivo analysis of “mCD4-HS12”, a synthetic glyco-conjugate which inhibits HIV entry. – HEPACLAMP
Human immunodeficiency virus (HIV-1), the virus that causes AIDS has infected 60 million people (half of which has died) and remains one of the leading causes of death worldwide. The availability of some 25 drugs, most of which target HIV-1 enzymes, markedly improved patients’ outcomes. However, the
The main goal of this project is to produce software based on language processing and artificial intelligence that detects potential risks of different kinds (health, ecological, economical, etc.) in technical documents. We will concentrate on procedural documents which are, by large, the main type
Microfluidics which consists in handling fluids on a chip is a young emerging field that is revolutionizing several scientific research fields at the interface with life sciences. Handling on chip small quantities of biological liquid becomes possible while working in a parallel way with multiple pa
Validation of porous composite scaffolds for bone tissue regeneration in pre-clinical models – MATRI+
With regard to the number of patients encountering a surgical bone reconstruction and the ageing population, news developments in orthopaedic and cranio-maxillofacial surgery are expected, especially for non-union fracture, large bone defect and bone physiopathologies. Tissue engineering strategies
Vectorization of biologically active molecules for their selective delivery to target cells is a major objective since this strategy allows potentiating the activity of these molecules, but also limiting their side effects. In particular, selective addressing of antigens of vaccinal interest to dend
Shape Memory Starchy Resorbable Implant – IRMAS
The context of the present project concerns the minimally invasive surgery, used to place medical device under endoscopic control.Recent studies in this area aim to set up shape memory polymers with the ability to change their shape in response to an environmental stimulus (temperature, or humidity)
New neuroprotective and neuroregenerative compounds for Parkinson`s disease – ANTIPARK
Around 150.000 people in France are affected by Parkinson’s disease (PD) and 10.000 new cases are diagnosed every year. This is the 2nd motor handicap after cerebral vascular breakdown. PD is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. PD is determined at
Thermally Assisted Mechanical Dewatering – DMAT
Sustainable development requires the use of renewables as alternative feedstocks for fuel, chemical and material productions. Currently, share of renewable raw materials runs at best to a few percents but is expected to provide up to 20% by 2030. Herbaceous plants, grasses, leaves, stems are raw ma
Contactless inspection of tubular inner surfaces – InSITUbes
Tubular structures are used in most industrial sectors. Present in numerous industrial processes for the transport of reagents, their injection or cooling devices, they are found especially in the agro-food, energy, pharmaceutical, chemical, aerospace, transportation or biomedical. For many year
Viscoelastic characterization of industrial fluids using acoustical rheology. Application to cosmetics and concretes. – RHEACTIF
The material viscoelastic properties assessment covers a wide range of industrial and research problematics, particularly in cosmetics/pharmaceutics, cements/concretes, foods, polymers and petroleum products. It is indeed essential to understand and predict the mechanical dynamic behaviour of indust
The aim of the projet is to complete the proof of concept of a new process for the production of capsules of various size and shell composition. So far, the proof of concept is completed for particular class of capsules, namely the vesicles (also called liposome) where the shell consist of lipids or
MECanical Ablation for GRAPHene production – MECAGRAPH
Graphene is the only example of "bi-dimensionnal crystal" : it is made of a layer of carbon from which the stacking constitutes the graphite in the tri-dimensional space. It has been isolated for the first time in 2004. Since, because of its exceptional properties (electrical conductivity, mechanica
Targeting of the Tn antigen by a specific chimeric monoclonal antibody in ovarian cancer immunotherapy – ANTITN
Therapeutic monoclonal antibodies (mAb) specific for tumor-cell surface antigens are efficient at eradicating patients’ cancers. These enthousiastic results encourage us to develop new tumor-specific mAbs, mainly against cancers with bad prognosis like ovarian cancer. Tn is a glyco-peptidic antigen
Phosphorus-containing dendrimers: innovating molecules for the treatment of Rheumatoid Arthritis – INNO-THER-RA
Our project aims at proposing a new therapy against Rheumatoid Arthritis (RA). RA is considered an auto-immune and inflammatory disease affecting 0.5% of the population in developed countries (300,000 cases in France). It is characterized by bone resorption, due to giant multinuclear cells called os
The project entitled ‘NanoContactPrinter’ aims at developing a non conventional lithography instrument for high resolution microcontact printing. It fits with the ‘Axe thématique 3 : Information, Communication, Nanotechnologies’ of the Call. Its relevance is due to its high potential in terms of int
More and more general public mobile devices such as watches, mobile phone, GPS include an electronic compass to find their orientation in space. They provide advanced navigation capabilities, for example to indicate the direction in which a person or a vehicle is moving when GPS is not available, or
New line of high density plasmas with extended operating conditions : etching chamber prototype – APANAGE
The objective of the APANAGE project is to exploit recent results of fundamental research obtained in the PLASMODIE ANR "blanc" project (2006-2009) devoted to the development of new plasma sources. The performance achieved in terms of plasma density, extension of operating conditions (pressure, micr
TRAnslation: OEM-able, Unified, Integratable Environment and Resources for Operationalization – Traouiero
The Traouiero project aims at allowing the operationalisation of software tools and lingware techniques and resources developed up to now by the GETALP group of the LIG lab as operational prototypes. In the context of the Web 2.0, the GETALP proposed to replace the traditional paradigm of transla
Compact Bidimensional Sampling Spectrometer – CoBiSS
Fourier Transform Spectrometer (FTS) is the tool of choice for visible and IR spectral analysis. However, the FTS technique suffers from a lack of compactness and/or robustness due the presence of scanning parts. Furthermore, standard technologies make available cumbersome devices particularly in th
The Green Lion® project is dedicated to the valorisation of a specific Li-Ion technology developed by CEA and combining Bipolar architecture on Aluminium current collector and the use of 2 advance Li-Ion materials Lithium Iron Phosphate (LFP) at the positive electrode and Lithium Titanate (LTO) at t
This project relates to a method for imaging biological compounds using a non intrusive high resolution surface plasmon resonance microscopy method that we refer to by ``BIOPLASMOSCOPE''. Imaging biological objects in liquid media, from nanoscale to microscale is a key issue of current research i
Plasma concentrations of HDL cholesterol (HDL-C) and its major protein component apolipoprotein (Apo) A-I are strongly inversely associated with cardiovascular risk, leading to the concept that therapy to increase HDL-C and ApoA-I concentrations would be antiatherosclerotic and protective against ca
Malaria is one of the most widespread parasitic infections in the world, infecting more than 300 to 500 million people and is responsible for the death of 1 million people a year. The spreading of Plasmodium falciparum infection is due to the emergence of resistance to almost all available antimalar
In outdoor environment traditional perception systems are reaching technical limitations: ultrasounds are disturbed by wind while optical devices such as laser or vision are sensitive to changes in lighting, rain, mist or dust. Cemagref has been involved for several years in research to bring in
Bone autograft is the gold standard treatment to fill large bone defects but this method leads to frequent complications. To circumvent these side effects the strategy followed by many research groups consists in using mineral scaffolds combined with osteogenic cells obtained from bone marrow or adi
HYbrid BIOelectronic endocrine PAnCreas Sensors (Screening and therapy in diabetes) – HY-BIOPACS
The project objective is to develop a drug/toxicological screening device with automated signal interpretation for long-term and online functional exploration of islets The context for this research is: a. The incidence of diabetes is progressing world-wide. Clearly, adapting newer technologies
Cost-effective composite substRatE for Advanced GaN applicaTIons : DeVEloPment and evaluatIon – CREATIVEPI
Wide bandgap technologies, and more particularly the GaN technology, introduce new possibilities in the landscape of power electronics and microwave through intrinsic qualities superior to silicon and III-V conventional technologies. The rapid evolution of this technology over the last decade is due
Preclinical study of a new innovative peptide therapy for a causative treatment of sepsis – LR17 peptide therapy in sepsis
Sepsis exemplifies a complex clinical syndrome that results from a harmful and damaging host response to severe infection. Sepsis develops when the initial, appropriate host response to systemic infection becomes amplified and then dysregulated. One of the amplifiers of the inflammatory response is
transferrin and ocular therapy – oculotransferrine
ABSTRACT Retinal degeneration has been associated with iron accumulation in age related macular degeneration (AMD) and in several rodent models which had one or several iron regulating proteins impairment. All cells require iron for survival and as a cofactor of a variety of enzymes ( However, it
Innovative extraction to crystallization technology of functional membrane proteins in solution – MPEC
The global protein therapeutics market will be worth $77 billion (bn) by 2011 (RNCOS, 2010, May). Beside, the global proteomic market is expected to increase from $7.9 bn in 2009 to $19.4 bn in 2014, for a compound annual growth rate of 19.7 % (BCC Research Report, 2009, June). This market deeply de
Les praticiens sont en permanence à la recherche de biomarqueurs permettant d’établir un diagnostic plus précis et plus rapide. Le domaine du rayonnement lumineux moyen infrarouge (longueurs d’ondes comprises entre 2 et 14 µm) contient l’essentiel des signatures spectrales des molécules biologiques
The major aim of this project is the perfection of an innovative 3D cell culture technology, that supports proliferation and development of various cell types. The 3D cell culture technology permits a more realistic environment in comparison with that of traditionnal cell culturing, regarding carac
Optimization of software for high quality technical writing: a pilot application in the field of health. – Sensunique
« Sensunique » is a project based on the concept of a Controlled Language applied to technical writing (protocols, instructions, alert messages). This project aims to optimize a computerized writing assistant and to validate its operational reality on a corpus of medical and healthcare texts. The o
The determination of volatile fatty acids (VFA), thiol compounds and amino compounds in environmental or biological samples require pre-treatment of samples (eg extraction) and expensive analytical techniques which not suitable for on-site measurement. However the determination of some of these chem
Study and fabrication of Membrane-electrodes Assembly by plasma Directe deposition on high perfomance electrolyte membrane. – AMADEUS
Developping and improving new environnementally friendly energy sources is matter of a great attention. In the field of fuell cells, it is highly required to significantly reduce the fabrication costs. This means that progress should be done regarding fabrication technologies, catalyst content reduc
Substitution for the lack or absence of saliva in patients treated with irradiation for head and neck cancer – S-Alive
All demographical studies show a constant increase in cancers in the head and neck region, whose annual frequency of new cases is estimated at over 400 000 in the world. In France, the annual incidence of cases of cancer of the lip, oral cavity and pharynx relate to about 15 000 new patients per yea
The objective of RUBI-CLOCK is to bring the concept of a compact atomic clock based on cold atoms to a technology readiness level that will allow a transfer towards industry. Compared to the compact caesium clock successfully developed at SYRTE over the last 10 years, the global objective of the RUB
Redox-active 1,4-naphthoquinones to kill malarial and schistosomal parasites – SCHISMAL
Our previous work led to the selection of potent antimalarial 2-benzyl-3-methyl-1,4-naphthoquinones (benzylNQ) active against various multi-resistant strains of Plasmodium falciparum and in P. berghei-infected mice (intraperitonnally and per os) and not toxic in animals. The compounds are devoid of
Development and commercialization of optimal microscopes for membrane potential optical recording – Voltimagmicro
The understanding of the brain relies on the analysis of electrical and chemical activity from multiple sites of neurons, in particular those sites where synaptic signals originate. This concept also applies to the study of functional deficits in animal models with the ultimate goal of understanding
Anti-microbial compounds targeting the alternative thymidylate synthase ThyX – AMTHYX
The growing problem of antibiotics resistance points to an urgent need for new anti-infective therapies. However, the rate of new antimicrobial compounds to be developed by the pharmaceutical industry alone will not be sufficient to meet the expected need for the foreseeable future. Therefore, activ
CXC chemokines in neovascular eye disease – CHEMO-NED
Angiogenesis inhibition has led to impressive results in clinical trials in a variety of human cancers. Most anti-angiogenesis strategies are based on the inhibition of VEGF. Another field where anti-angiogenesis treatments are important is ocular diseases associated with neovasculrization. Current
Influenza is one of the most common infectious diseases in humans occurring as seasonal epidemic and sporadic pandemic outbreaks. The ongoing infections of humans with avian H5N1 influenza A viruses (IAV) and the ongoing pandemic caused by recently emerged swine-origin H1N1 viruses highlights the pe
Customized broadhand services for the elder – AMALYS
The aging population is a very strong concern in Europe. The significant increase in life expectancy leads to worry about increasing the quality of life of seniors. There is a strong link between aging and loneliness. The objective of the Amalys project is to bring maturing part of six years of r
The Ecole des Mines de Nantes, and more precisely the Ascola team, has been developping a sofware called Entropy under the LGPL open source license since 2006. This software is an auomonomic framework aiming to manipulate virtual machines in data centers. In the cloud computing terminology, Entropy
Mediator-less Glucose BioFuel Cell – M-GBFC
Glucose BioFuel Cells (GBFCs), whose redox reactions are catalyzed by enzymes, hold a strong place in worldwide research. Though their first targeted application was implantation inside animals, this implantation had never been performed. Classical GBFC’s enzymes indeed present characteristics that
Improvement of assisted reproductive techniques by phospholipase A2: the primate assay. – LUTINFER
Currently, assisted reproductive techniques (ART) are widely used in human reproduction and more than 2% of children are born using these techniques in Western countries. In vitro fertilization (IVF) was a major discovery and allowed for infertile parents to obtain children. IVF is based on the mixi
Diseases of the heart and the cardiovascular system are the leading cause of mortality in France, accounting for > 180 000 deaths per year. Their incidence is expected to increase further in the next five decades due to rising life expectancy, obesity and type II diabetes in the general population.
A first objective of this project is to validate molecular markers previously identified to identify oak trees to the species level and to source oak wood lots used by the barrel industry. A second one is to make these markers available to all interested end-users. Hence, it will become possible by