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Biomarkers for electromagnetic exposures to future wireless systems – BioREF
Possible health hazards due to utilization of electromagnetic field in telecommunication technologies represent nowadays a major public worry. Due to the saturation of the lower part of the electromagnetic spectrum and the need of very high data rate transmissions, the operating frequencies of emerg
Structural Adaptive Response of the Aryl hydrocarbon Receptor (AhR) to Xenobiotics: Implication in predicting the toxicity of pollutants in both humans and ecosystems – PlasticAhR
Contamination of ecosystems and organisms by environmental pollutants are among the major health concerns of the twenty first century. Over the last decades, toxicities of some xenobiotics have been characterized. However, despite intensive research, our ability to predict the toxicity of persistent
Pharmaceutical residues and ecotoxicology in seawater – Pharm@ecotox
* * * * The pharmaceutical substances represent a diverse collection of over 1000 biologically active molecules used in human and veterinary medicine. Increased consumption of drugs and the development of more powerful analytical techniques in environmental resulted in the identification of these em
Production of mycotoxins in wheat: from the diversity of the Fusarium community to the toxicological impact of mycotoxins. – DON&Co
Food safety is a major issue in France and in the world. In this respect, much attention requires to be paid to the possible contamination of food and feed by fungi and the risk of mycotoxin production. Mycotoxins are frequent contaminants of cereal. According to survey data published by ONU, 25 % o
Genotoxicity biomarkers ex vivo et in vivo. – GENOTOXTRACK
Genotoxic substances induce DNA damage. DNA double-dtrand breaks (DSBs) are considered the most lethal form of DNA damage as they can result in cell death and, if misrepaired, they have the potential to result in chromosomal translocations and genomic instability. The H2AX protein phosphorylation
Hepatitis E dynamics in related ecosystems: from pig farms and wastewaters to shellfish – HEVECODYN
Hepatitis E virus is responsible for an acute Hepatitis similar to Hepatitis A but usually more severe with anorexia, jaundice and liver enlargement. Although HEV infection is associated with a low mortality rate, fulminate hepatitis requires liver transplantation which is a very demanding and expen
Toxicity and Internalisation mechanisms of titanium oxide Nanoparticles In eukaryotic and Multicellular Specimens – TITANIUMS
The explosive growth in nanotechnology, which refers to the study and design of systems at the atomic or nano- scale, and in bioengineering fields has led to a large number of new nanomaterials in order to create unique devices with novel targeted physical and chemical functional properties. Most of
Xenobiotics, endocrine disruption and neurotoxicity: impact of chronic exposure to pesticides on reproduction, development and function of the central nervous system of a mammalian model. – Neuropest
Pesticides are a real problem of public health not only for users who are the most exposed, but also for general population. Epidemiological studies of populations exposed to these toxics suggest an increased of cancer risk, birth defects, infertility, neurodegenerative diseases and immune deficienc
Rhizostabilisation of highly heavy metal contaminated mine spoils by using METALlicolous plants associated with microbial SYMbionts – SyMetal
Numerous degraded land areas resulting from industrial or mining activity are still remaining in France and in Europe. Most of those areas were not restored before being abandoned and constitute "hot spots" of metal pollution. Moreover, under the action of water and wind erosion, the metal pollution
Early life effects of Bisphenol A on the maturing gut barrier and metabolic programming in the liver and adipose tissue: long term consequences in adulthood – PerinaTox
In the last decade evidences have accumulated that exposure to low doses of endocrine disruptors during the foetal and neonatal periods may favour the emergence of diseases in adulthood. Regarding the striking example of diethylstilbestrol prescribed to pregnant women from the 1940s to the 80s, rece
Integration of selective tools for the determination of Ochratoxin A: diagnostic methods for the assesment of the toxicological risk – MYCODIAG
x x x x Ochratoxin A (OTA) is the most common mycotoxin found in our temperate regions that contaminates food commodities prior to harvest or more commonly during storage. OTA inhibits protein synthesis and lipid peroxidation by oxidative processes. These mechanisms may generate nephrotoxic, neuroto
Effects of radiofrequency exposure in aged and Alzheimer’s disease mice: a combined behavioural and neurovascular approach – READ
READ: Effects of radiofrequency exposure in aged and Alzheimer’s disease mice: combined behavioural and neurovascular studies Environmental exposure to radiofrequency (RF) fields is increasing worldwide due to the development of wireless communications. First confined to mobile telephony network
Effects of chronic exposure of Airways to house Dust mite on bronchial asthmatic smooth muscle Mitochondria – AirDustMito
This project will evaluate the effect of chronic exposure to house dust mite (HDM) on the bronchial smooth muscle (BSM) remodelling observed in asthma and particularly the number of mitochondria. Indeed, the increased number of mitochondria is a key factor of BSM remodelling. The increased mass of B
Degradation and transfer of polyacrylamide based floculents in sludges and industrial and natural waters - Potential impact on aquatic ecosystem – AquaPOL
Flocculants are widely used in several industrial fields (mineral extracting, chemical industry, food processing industry, treatment of drinking water) to enhance solid/liquid separation in water containing suspended matter. In France, mineral extracting industry is one of the major users of floccul
What alternatives to the chemical control of Chagas disease vectors? – ALTERNATIVES
Chagas disease or American Trypanosomiasis is an essentially rural disease which affects 20 million people in South America. Transmission to man is mainly the fact of hematophagous bugs of the Reduvidae family of which Triatoma infestans, a main vector in the Southern Cone countries (Argentina, Boli
Contaminants in POLAR TOP Predators : Levels and effects of persistent organic pollutants and Heavy metals on stress physiology and fitness in Antarctic seabirds – POLARTOP
Biodiversity in Antarctica is characterized by spectacular colonies of seabirds and sea mammals. Despite their remote location, Polar Regions are subject to anthropogenic (metals and organic pollutants) inputs due to global transport of elements in the atmosphere and through oceanic circulation. Ant
Mechanisms of accumulation, elimination and disturbances of the nervous and endocrine systems induced by chlordecone in Macrobrachium rosenbergii in the French West Indies. – MACHLOMA
In the French West Indies, chlordecone was used on bananas till the beginning of the ‘90s. This resulted in a highly persistent contamination of soils, water and living organisms. In freshwater environments, crustaceans present high concentrations of chlordecone in their organs. Therefore, more seve
Emerging perfluorinated contaminants: contribution to the human exposure assessment, to the study of their metabolism and to the characterisation of their toxicological impact. – CONTREPERF
Perfluorinated compounds (PFCs) are synthetic chemical substances produced and used to exploit their hydrophilic-lipophilic balance through anti-sticking material or surfactant related products. Consequently, consumers from industrialised countries are today in contact with these chemicals in their
BIological, Structural and COmputational Tools to study nuclear hormone receptors and endocrine disruptors interactions – BISCOT
Human nuclear hormone receptors (NHRs) are a family of 48 transcription factors, many of which have been shown to be activated by ligands. NHRs regulate cognate gene networks involved in key physiological functions such as cell growth and differentiation, development, homeostasis or metabolism. As a