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The risk of falls for the elderly is a major public health challenge. Fall prevention requires better knowledge and understanding of the multiple processes involved in the balance maintenance and of their interactions: neurological, cognitive, and psychological processes allowing the regulation of t
Subarachnoid hemorrhage (SAH) occurs in the setting of a ruptured cerebral aneurysm or arteriovenous malformation (AVM). The socio-economic impact of SAH is important because it affects young subjects with around one third of the survivors who maintain severe neurological aftereffects. SAH leads, in
During the development of new therapeutics against brain diseases, the pre-clinical phase, i.e. the validation of treatment delivery, safety and efficacy in animal models of the disease, represents a crucial step. Magnetic Resonance Imaging (MRI) is a method of particular interest at this stage, as
BIOcompatible and BIOfunctional porous electrodes for miniaturized enzymatic biofuel cells – BIO3
The objective of our work is to design a fully integrated, extremely miniaturized and perfectly biocompatible glucose/O2 biofuel cell (BFC) as an in-vivo source of electricity that may power for example, a subcutaneously implanted, continuous glucose monitor for diabetes management. However, nume
Because of ageing, various life trauma and bone diseases, bone grafts and bone substitutes are being used to replace missing or no longer viable bone tissue. The number of bone grafting procedures will in the next decade reach 500 000 in 2020 in Europe and the sales volumes of high performance synth
This project aims to develop a brand new light sensor array for biomedical applications. It is designed to meet the criterion of "non-invasive blood glucose monitoring". It is thought to meet the requirements of the treatment of diabetes type I. In addition it is built around a scalable technology:
Prostate cancer is by far the most common cancer for men. A vast variety of prostate cancer treatments are today performed in clinical routine. However, most of them act on the entire gland and are characterized by a high rate of side effects that considerably impact the quality of life of the patie
Parkinson's disease (PD) and multiple system atrophy (MSA) are neurodegenerative disorders. The latter belongs to the group of atypical parkinsonian disorders and has a poor prognosis. In early stages of the disease, PD and MSA symptoms are very similar, particularly in MSA-P patients where parkinso
Ventricular fibrillation (VF) is the most deadly cardiac arrhythmia with a grim survival rate of 20 J to
In numbers of pathological states (ischemia, or a delay in electrical conduction), regional differences in contractility may induce significant asynchronous contractions. As opposed to the normal LV, where all segments contract almost synchronously and myocardial energy is used effectively, asynchro
Prevention is central for the national health strategy. The e-health tools may be useful to change the medical practice and to make patient involved in prevention. The objective of PEPS is to develop computer based tools to make effective the prevention approach for both physician and patient. The p
Tattooing is a practice dating back from the Neolithic. Several bodies, discovered in the permafrost or well-conserved mummies were bearing tattoos. Permanent body painting has therefore found its way through the ages and civilizations. Nowadays, 45 millions of US citizens are tattooed. In France, s
When not fatal, strokes cause injuries leading to motor disabilities. Thus, it is estimated that 24% to 74% of the 50 million stroke patients worldwide would be more or less dependent on technical aids or their relatives for activities of daily living such as walking, toileting, dressing, preparing
Falls in the elderly has become a major public health issue, as it leads to about 4800 deaths in France and to important health expenses (about 1 billion euros per year). To address this issue and enable individuals to stay home with the best autonomy and security conditions possible, the PRuDENCE
Lung's secretions capture the external pollutants (either chemical or biological) and the natural motion of secretions up the bronchial tree lead these pollutants outside the lungs. Motion of secretion is achieved thanks to two main mechanisms: the beating of cilia standing on the epithelium cells,
In France, 300 000 people suffer from a strong speech disorder and more than 5 millions worldwide, often following brain strokes but also in case of severe tetraplegia, locked-in syndrome, neurodegenerative disease such as Amyotrophic Lateral Sclerosis or Parkinson’s disease, myopathies, or coma. Th
This project aims to develop an implantable biofuel cell able to convert chemical energy into electric energy through abiotic transformation of glucose and O2. Main advantage of abiotic biofuel cells is that chemical reactions are not catalyzed by enzymes but by chemical compounds resulting from the
Fluorescence microscopy is by far the most used optical imaging technique for biological investigations due to its non-invasiveness and the high molecular specificity of fluorescent labeling. Recent developments in super-resolution fluorescence microscopy in addition to the increase of available gen