HOPE-Epidémiologie – Recherche épidémiologique en Hémato-Oncologie Pediatrique

The HOPE-EPI/CCOP infrastructure is dedicated to pediatric oncology research on (1) Environmental and genetic risk factors, (2) Evaluation of the management of childhood cancers in real life, (3) Iatrogenic effects of treatments, and, more generally, (4) Short, medium and long-term health of survivors and the determinants of their quality of life.

Major progress has been made during this latest period. The COHOPER cohort now includes more than 40,000 cases, with detailed treatments for 27,000 of them. PEDIART dosimetry is assigned to all cases who had radiotherapy since 2013 (> 3,500). We collected questionnaire data for 6,600 (47%) of the adult survivors and obtained controls from the Constances cohort. GEOCAP includes nearly 22,000 cases at diagnosis with 63,000 controls, and has addresses at birth for 2,800 cases born since 2010 and 12,000 birth controls. We assessed residential exposures to agricultural activities, magnetic fields and air pollution. All our data is standardized and subject to quality controls.

We have completed the regulatory procedures for compliance with the GDPR and obtained agreement for individual linkage with the SNDS. HOPE-EPI/CCOP now provides the community with relevant and reliable data, essential for evaluating and adapting care and prevention recommendations, in a context of constantly evolving treatments. We have opened the data last year and have just integrated France-Cohortes. We published 13 articles, and several external projects have already started.

Being attached to the National Childhood Cancer Registry is a considerable asset, which allows to benefit from its exhaustiveness, basic data and quality data collection practices. Individual linkage with the SNDS will also be a tremendous asset. Such epidemiological monitoring of childhood cancer survivors, without selection bias, on a large country and a national scale, makes HOPE-EPI/CCOP unique and particularly powerful among existing infrastructures worldwide.