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Lyon - Imagerie Intégrée du Vivant : IRM-TEP hybride (LILI)


Action : Equipements d'excellence


N° de convention : 11-EQPX-0026

Informations générales

  • Référence projet : 11-EQPX-0026
  • RST : Olivier BERTRAND
  • Etablissement Coordinateur : Université de Lyon I (Claude Bernard)
  • Région du projet : Auvergne-Rhône-Alpes
  • Discipline : 5 - Bio Med
  • Aide allouée : 4 000 000 €
  • Date de début du projet : 01/06/2012
  • Date de fin du projet : 31/12/2019
  • Mots clés : Positron Emission Tomography; PET; Magnetic Resonance Imaging; MRI; Hybrid Imaging; in vivo imaging;

Résumé du projet

The Equipex LILI permitted to install the first French MRI-PET scanner at CERMEP, Lyon, in October 2014. This equipment consists of an innovative hybrid imaging platform composed of positron emission tomography and magnetic resonance imaging modalities for in vivo structural and functional exploration in a truly simultaneous way. This opens up innovative ways to study brain functions and diseases, cancers, cardiovascular dysfunctions, and nutritional and metabolic disorders. It enables the scientific community and industrial researchers to consolidate the position of excellence of France in in-vivo imaging. Phase one of the Equipex started June 1st 2012 and ended May 31st 2015, including all building works, equipment installation and regulatory approvals. Thirty research projects are identified and sixteen projects are already funded. Projects are exploring essential functions of the central nervous system, vital organs such as the heart and kidney. End of 2016, 4 projects are completed, 7 are in progress, and eight are ready to start. 37% of the projects are dedicated to clinical research in neurology, 25% in neuroscience, 13% in cardiology, 13% in oncology, 4% in psychiatry, 4% in nephrology and 4% in methodology. This Equipex benefited from support and research staff from the CERMEP, and developed synergistically with IHU-B CESAME allowing recruiting additional support personnel for 3 years: 2 radiochemical technicians and one MRI specialist. Thanks to a tight collaboration with SIEMENS Healthcare, 2 CIFRE PhD thesis were recruited and already produced results on an innovative cerebral tissue attenuation correction method that could be disseminated in all MRI-PET systems. Three post-doctoral researchers (funded by Siemens or Cesame) have started working on (1) PET 4D reconstruction using MRI information, (2) PET modelling method with MRI-PET image-based arterial input function, and (3) MR sequence development for pelvian and abdominal attenuation correction.  

(L'auteur de ce résumé est le coordinateur du projet, qui est responsable du contenu de ce résumé. L'ANR décline par conséquent toute responsabilité quant à son contenu.)